Immune Correlates of Cardiac Structure and Function

Inclusion Criteria: 1. Individuals 20-45 years of age 2. Willingness and ability to provide signed and dated written informed consent, prior to any study-related procedures 3. Diagnosed with HIV \<10 years of age or physician confirmation of perinatal HIV infection 4. On antiretroviral treatment (ART) for at least the last greater than or equal to 6 months 5. Willingness to undergo Cardiovascular magnetic resonance imaging (CMR) 6. Willingness to undergo echocardiogram (ECHO) (may be included if ECHO has been done at Duke in the previous 24 months). 7. Willingness to have research blood draw Exclusion Criteria: 1. Contraindication to CMR (metal fragments in eyes or face, implanted electronic devices such as pacemakers, defibrillators, cochlear implants, or nerve stimulators, aneurysm clips) 2. Estimated glomerular filtration rate (eGFR) \< 30 mL/min/1.73m2 3. History of anaphylactic reaction to gadolinium contrast 4. Inability to complete an MRI scan in the past due to anxiety 5. Recent acute medical illness resulting in recent hospitalization (in past 90 days) 6. History of: Coronary artery disease (CAD), Myocardial infarction (MI), moderate-severe valvular disease, congenital heart disease, heart failure, non-ischemic CM, Atrial fibrillation/flutter, implantable cardioverter defibrillator (ICD)/pacemaker, myocarditis prior 7. Current Symptoms of Shortness of breath, severe chest pain, palpations, difficulty breathing on exertion, swelling of legs 8. Known to be pregnant or current breastfeeding 9. Known to be on hemodialysis 10. Inability to breath hold for 5-10 seconds 11. Known to have an ejection fraction \<45% in the past 24 months 12. Active cancer or cancer chemotherapy or radiation treatment in the prior year. 13. Comorbid inflammatory disease, specifically treated for rheumatoid arthritis (RA) or lupus (SLE) 14. Chronic use of steroids or anti-inflammatory therapy