Local and Systemic Changes in Osteonecrosis of the Jawbone

N/AEnrolling By InvitationNCT05329558

Medical University of Graz100 enrolled

Overview

Osteonecrosis of the Jawbone (ONJ) is a serious complication of antiresorptive therapies (ARTs), for example with bisphosphonates or Denosumab. Especially long term treatment with intravenous antiresorptive agents causing lesions and, less frequent, also oral administration. This study aims at elucidating local and systemic changes in patients with ONJ.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Osteonecrosis of the Jaw

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years or older * with/without ART * with/without MRONJ Exclusion Criteria: * smoker (\>10 cigarettes/day) * pregnancy

Locations (1)

Medical University of Graz

Graz, Austria

Outcomes

Primary Outcomes

target gene expression

differences in gene expression recorded by qPCR will be assessed

Time frame: through study completion, an average of 1 year

Data from ClinicalTrials.gov

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