Study to Evaluate Safety, Tolerance and Efficacy of ASC22 Combined With ART in Subjects With HIV

Inclusion Criteria: * Age ≥18 and ≤ 60 years old at screening. * Treated with anti-retroviral medicine continuously for at least 12 months within 6 months of diagnosis of HIV-1 infection. * Treated with anti-retroviral medicine continuously, contain integrase inhibitor, for at least months before screening. * CD4+ Cell count ≥300 cells/μL and CD4+/ CD8+ratio ≤ 0.9 at screening. * Weight ≥ 50 kg at screening. Exclusion Criteria: * Known allergy to the drug or excipients used in this trial. * HIV-associated opportunistic infections in the past 5 years. * Co-sensors of HBV, HCV, syphilis, etc. * With bleeding disorders or on anticoagulant therapy.