This study will examine the differences in microcirculatory function and mitochondrial respiration in patients with shock after cardiovascular surgery.
Post-cardiotomy shock (PCS) occurs in up to 5% of cardiovascular surgeries and has an in-hospital mortality rate as high as 75%. It is unclear if patients with PCS despite achieving standard resuscitation goals have impairments in oxygen delivery or oxygen utilization. This study will examine the difference in microcirculatory function and mitochondrial respiration in patients with shock to better understand the driving mechanism of bioenergetic failure in patients with PCS.
Study Type
OBSERVATIONAL
Enrollment
142
cardiovascular surgery with cardiopulmonary bypass
University of Pennsylvania
Philadelphia, Pennsylvania, United States
Perfused Vessel Denisty (PVD)
Perfused vessel density (PVD) was measured with incident darkfield microscopy (units mm/mm\^2)
Time frame: PVD was measured at baseline (immediately prior to surgery), at ICU admission, approximately 4 hours after surgery, then at 24 hours.
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