A cross sectional study to assess the effect of blood transfusions on the outcome of preterm infants
This is a cross sectional study carried on preterm infants who are staying in the hospital as "growers"; to gain weight. We will assess blood transfusion received by these preterm infants in details.
Study Type
OBSERVATIONAL
Enrollment
40
Change in heart rate
Heart rate per minute
Time frame: immediately before and immediately after blood transfusion
Change in respiratory rate
Respiratory rate per minute
Time frame: immediately before and immediately after blood transfusion
Change in weight gain
Average weight gain in grams/kg/day
Time frame: within 4 days before and within 4 days after blood transfusion
Change in hemoglobin
Hemoglobin in grams/dl
Time frame: immediately before and immediately after blood transfusion
Change in hematocrit value
Hematocrit value percentage
Time frame: immediately before and immediately after blood transfusion
Acute blood loss
Acute blood loss either spontaneous or iatrogenic during invasive procedures
Time frame: in the previous 24 hours before blood transfusion
Mechanical ventilation
Mechanical ventilation (MV) which may be one of two possibilities: 1. Moderate or significant MV; Mean airway pressure (MAP) \>8 cm H2O on conventional ventilator or \>14 cm H2O on high frequency ventilator and FiO2 \>0.4 2. Minimal MV; MAP ≤8 cmH2O on conventional ventilator or ≤14 cm H2O on high frequency ventilator and FiO2 ≤ 0.4
Time frame: in the previous 24 hours before blood transfusion
Supplemental oxygen
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Supplemental oxygen, not mechanically ventilated
Time frame: in the previous 24 hours before blood transfusion
Doubling of oxygen requirements
Doubling of oxygen requirements for patients on supplemental oxygen
Time frame: in the previous 2 days before blood transfusion
Tachycardia
≥24 hours of tachycardia (Heart rate\>180/minute)
Time frame: in the previous 24 hours before blood transfusion
Tachypnea
≥24 hours of tachypnea (Respiratory rate\>60/minute),
Time frame: in the previous 24 hours before blood transfusion
Poor weight gain
≤10 g/kg/day while the infant is receiving ≥120 kcal/kg/day
Time frame: in the previous 4 days before blood transfusion
Metabolic acidosis
pH \<7.2
Time frame: in the previous 24 hours before blood transfusion
Apnea and bradycardia
9 episodes or ≥2 episodes requiring bag and mask ventilation, while infant is receiving caffeine citrate
Time frame: in the previous 24 hours before blood transfusion
Length of stay in the NICU
Length of stay in the NICU
Time frame: from date of birth until the date of transfer to the "grower ward" or date of death from any cause, whichever came first, assessed up to 3 months.
Length of stay in the hospital
Length of stay in the hospital
Time frame: from date of birth until the date of discharge home or date of death from any cause, whichever came first, assessed up to 3 months.
Mortality
Death
Time frame: from the date of transfer to grower ward, assessed up to 3 months.