Cardiac T1 Mapping Enables Risk Prediction of LV Dysfunction After Surgery for Aortic Regurgitation

Universitätsklinikum Hamburg-Eppendorf40 enrolled

Overview

To assess whether cardiac T1 mapping for detection of myocardial fibrosis enables preoperative identification of patients at risk for early left ventricular dysfunction after surgery of aortic regurgitation.

We hypothesized that a diffuse interstitial myocardial fibrosis may be present in AR patients who experience early systolic LV dysfunction after aortic valve surgery. We aimed to evaluate the association between preoperative cardiac T1 mapping for detection of myocardial fibrosis and early systolic LV dysfunction after surgery for aortic regurgitation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aortic Regurgitation

Interventions

aortic valve surgeryPROCEDURE

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Consecutive patients with severe aortic regurgitation referred for aortic valve surgery were prospectively enrolled in the study. Exclusion Criteria: * history of coronary artery disease * acute aortic valve disease (i.e., type A aortic dissection or infectious endocarditis) * common contraindications for MRI such as severe obesity and metallic foreign bodies.

Outcomes

Primary Outcomes

Native T1

Measured with MRI

Time frame: baseline (Prior surgery)

Data from ClinicalTrials.gov

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