Dietary Impact on Intestinal Sulfate Metabolism

University of Minnesota15 enrolled

Overview

This is a 5-week crossover pilot study of 15 highly motivated healthy volunteers who will consume two 7-day intervention diets: 1) a diet low in sulfur-containing amino acids (Low-S diet), emphasizing plant-based foods and fat sources; and 2) a diet high in sulfur-containing amino acids (High-S diet), emphasizing animal protein and fat sources. A 14-day washout period will follow each intervention, in which participants will eat their typical diets.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Healthy Nutrition

Interventions

Plant-Based Diet then animal-based dietBEHAVIORAL

Participants started with plant based diet: high in fiber, low in animal products for 7 days, with 14 day washout period between interventions. Following that, participants were switched to animal-based diet: high in animal products, low in fiber for 7 days.

Animal-based diet then plant-based dietBEHAVIORAL

Participants were started with animal-based diet: high in animal products, low in fiber for 7 days, with 14 days washout period between interventions. Following that, participants were switched to plant-based diet: high in fiber, low in animal products for 7 days

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Provide informed consent * Ambulatory and community dwelling * Able and willing to comply with the study schedule and procedures * 18 - 80 years of age * BMI between 18.5 - 40.0 kg/m2 * Omnivorous or willing to consume animal products through duration of study Exclusion Criteria: * Antibiotic use within 3 months * Planned antibiotic therapy within the period of the study, e.g., perioperative antibiotics. * Use of sulfonamides or sulfasalazine, as these sulfur-containing medications may confound results * Use of 5-aminosalicylates (5-ASA), as they are known to inhibit sulfidogenesis * History of anaphylactic food allergies, e.g., peanuts, seafood. * Food intolerances and allergies, including gluten sensitivity, lactose intolerance, and intolerance of high fiber dietary content. * Strict vegan eating practices, with refusal to consume animal products. * Planned use of oral probiotics while on study. * Serious, concomitant illness that, in the opinion of the Investigator, would interfere with evaluation of safety or efficacy, or put the participant at risk of harm from study participation. * Significant alcohol use, defined as \> 20 g/day in females and \> 30 g/day in males for a period of 3 months within one year prior to screening. * Underlying chronic gastrointestinal disease that can cause diarrhea, including short bowel syndrome, irritable bowel syndrome, malabsorption, and celiac disease. * History of partial or complete colectomy. * History of malabsorptive bariatric surgery. * Currently participating in another clinical study. * Legally incompetent and unable to understand the study's purpose, significance and consequences, and to make decisions accordingly.

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Effect of Short-term (1-week) Plant- and Animal-based Eating Patterns on Hydrogen Sulfide Production

Determine the effect of short-term (1-week) plant- and animal-based eating patterns on ex vivo fecal hydrogen sulfide production in healthy human volunteers We will measure fecal hydrogen sulfide production ex vivo in ppm/g of dry weight of stool

Time frame: Following 1-week of plant- and animal-based eating patterns

Data from ClinicalTrials.gov

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