The purpose of the proposed study is to evaluate the efficacy of dronabinol for postoperative pain after arthroscopic surgery of the knee. The investigators hypothesize that dronabinol will relieve pain, reduce opioid consumption and will result in few negative side effects. If this pilot study shows promising results the investigators will expand the trial to include additional arthroscopic surgeries (hip, shoulder) and other types of orthopaedic surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
30
5mg 2x daily for 7 days
1 caplet 2x daily for 7 days
Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
RECRUITINGOpioid consumption
Count of number of hydrocodone/acetaminophen tablet consumed
Time frame: up to 7 days post-surgery
Pain Visual Analog Scale (VAS)
Scored from 0 (no pain) to 10 (worst possible pain)
Time frame: up to 7 days post-surgery
Patient-Reported Outcomes Measurement Information System (PROMIS) Bank v1.1 - Pain Interference
PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50 and standard deviation of 10 in a reference population (usually U.S. general population). A low score indicates less pain interference (better outcome) and a high score indicates more pain interference (worse outcome).
Time frame: up to 21 days post-surgery
PROMIS Bank v2.0 - Pain Behavior
PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50. A low score indicates less pain (better outcome) and a high score indicates more pain (worse outcome).
Time frame: up to 21 days post-surgery
PROMIS Bank v2.0 - Physical Function
PROMIS measures generate T-scores. T-scores are standard scores with a mean of 50. A low score indicates worse physical functioning and a high score indicates better physical functioning.
Time frame: up to 21 days post-surgery
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