The objective of this project is to evaluate the postprandial serum and plasma vitamin and mineral levels in healthy adult men and women between 18 and 32 years of age, following a single intake of a multivitamin and mineral supplement processed in two different ways.
Serum or plasma levels of five vitamins and four minerals will be measured at baseline, and 1, 2, 4, and 6 hours after the intake of a multivitamin/mineral supplement processed by two different methods. The two methods involve using either conventional isolated vitamins and minerals blended together to provide approximately 100% of the Daily Value, or using the same amount of vitamins and minerals that have first been processing into liposomal forms before blending. Participants are required to come for two study visits which are 5 to 7 days apart. Health screening will also be done at Study Visit 1. The order of supplement assignment will be randomized, performed in a double-blind manner.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
17
Oral administration of Supplement A
Oral administration of Supplement B
Ragle Human Nutrition Research Center
Davis, California, United States
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum Vitamin A
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum folate
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum Vitamin D
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum Vitamin B-12
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of plasma Vitamin C
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum zinc
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum iron
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Total area-under-the-curve of serum manganese
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
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Total area-under-the-curve of serum magnesium
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of Vitamin A (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of folate (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of Vitamin D (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of Vitamin B-12 (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum plasma level of Vitamin C (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of zinc (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of iron (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of manganese (mg/dL)
Time frame: 6 hours
Assess the serum or plasma levels of five vitamins and four minerals
Maximum serum level of magnesium (mg/dL)
Time frame: 6 hours