The purpose of this study is to determine the intra-articular and serum levels of vancomycin over the first 24 hours postoperatively after intra-articular administration of a standard dose of vancomycin in primary total knee arthroplasty.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
100
After closure of the arthrotomy, 1 g of vancomycin powder suspended in 30ml of normal saline was injected directly into the joint with an 18-gauge needle.
The affiliated hospital of Qingdao University
Qingdao, Shandong, China
Intra-articular vancomycin concentration
Time frame: 2 hours, 8 hours and 24 hours postoperatively
Serum vancomycin concentration
Time frame: 2 hours, 8 hours and 24 hours postoperatively
Renal function
blood urea nitrogen (BUN), creatinine (Cr), GFR
Time frame: Postoperative Day 1 and Day 3
Blood loss
Time frame: Postoperative Day 3
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