Effect of Exogenous Growth Hormone on Ocular Findings

Isfahan University of Medical Sciences90 enrolled

Overview

Body size and eye function play an essential role in adapting to the environment and human survival. Growth hormone is commonly recognized by its effect on the height of individuals; Although from an evolutionary perspective, the effects of growth hormone on eye development are more important. Although the effect of growth hormone on eye development has not been accurately determined, the results of a number of studies suggest the effect of growth hormone on eye development. Despite the large number of studies that have investigated the effects of growth hormone on height growth, there are few studies that have investigated the effects of growth hormone on the eye. To the best of our knowledge, no study has been conducted to investigate the effect of growth hormone on ocular findings of patients with early or precocious puberty. Therefore, we intend to investigate the effect of growth hormone on ocular findings of patients with early or precocious puberty.

Investigators will achieve the following data from the participants: 1. Demographics 2. Past medical history 3\. Bone and calendar age 4- Stage of puberty 5- Ocular examination 6\. Ocular biometry

Study Type

OBSERVATIONAL

Enrollment

Conditions

Precocious Puberty Early Puberty Refraction Error

Eligibility

Sex: ALLMin age: 4 Years

Medical Language ↔ Plain English

Inclusion Criteria: Sample group (with early or precocious puberty): 1. Children with precocious puberty based on Tanner classification 2. Girls 4 to 10 years old 3. Boys aged 4 to 11 4. No known eye problems including: history of eye trauma, eye surgery 5- lack of family history of glaucoma or increased intraocular pressure 6\. Lack of previous history of receiving growth hormone 7. Lack of systemic disease or known syndromes 8. Consent to participate in the study Exclusion Criteria: 1. Incidence of growth hormone adverse reactions leading to discontinuation of treatment 2. Changing the patient's treatment plan during the study 3. Ocular complications requiring treatment during the study 4. Unwillingness of the patient to continue participating in the study

Outcomes

Primary Outcomes

Refraction Error

Comparison of the refraction error between the study groups

Time frame: 6 months

Axial Length

Comparison of the axial length between the study groups

Time frame: 6 months

Secondary Outcomes

Papillitis

Comparison of the frequency of papillitis between the study groups

Time frame: 6 months

Central Corneal Thickness

Comparison of the mean central corneal thickness between the study groups

Time frame: 6 months

Effect of Exogenous Growth Hormone on Ocular Findings

Overview

Conditions

Eligibility

Locations (2)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts