Exercise Target Brain Oscillations in Psychosis

University of Minnesota

Overview

Previous studies have shown that cardiorespiratory fitness (how well the heart and lungs are able to function during physical activity) is often reduced in people with psychosis. The goal of this research study is to test the hypothesis that aerobic exercise can lead to small changes in brain functioning that can influence visual perception and attention in psychosis. The type of aerobic exercise used in this study is called Sprint Interval Training, or "SIT". Information from this study will help to develop interventions that enhance cognition and maximize the quality of life for persons living with psychosis. The exercise procedure used is called SIT, which involves training rigorously on a stationary bike for a short period of time followed by a resting period.

Study Type

OBSERVATIONAL

Conditions

Psychosis Schizophrenia Schizoaffective Disorder

Interventions

Sprint Interval Training (SIT)OTHER

Active arm-- exercise dictated by protocol

Eligibility

Sex: ALLMin age: 18 YearsMax age: 64 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Meet diagnostic criteria for schizophrenia or schizoaffective disorder * Are age 18-64 * Fluent in written and spoken English * Have an outpatient status of at least 1 month prior to participation * Has been on a stable dose of psychiatric medication for at least one month prior to participation (titration to a lower dose of psychotropic medications under supervision of a psychiatrist can be allowed at the discretion of the investigators) Exclusion Criteria: * Current or possibility of current pregnancy (self-reported) * Active suicidal ideation at screening or baseline assessments, or previous intent to act on suicidal ideation with a specific plan, preparatory acts, or an actual suicide attempt within the last 3 months, as indicated by the C-SSRS * WTAR standardized score below 70 * American College of Sports Medicine contraindication to exercise

Locations (1)

University of Minnesota

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Change in Individual Alpha Frequency

A prominent neural oscillatory rhythm measured from resting EEG.

Time frame: through study completion, on average 2 weeks

Change in Visual Attention

Computerized tasks that measure speeded sustained attention.

Time frame: through study completion, on average 2 weeks

Change in Visual Perception

Computerized tasks that measure speeded visual perception

Time frame: through study completion, on average 2 weeks

Data from ClinicalTrials.gov

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