Primary Objective: To evaluate objective response rate (ORR) in adult patients with relapsed/refractory follicular lymphoma (r/r FL) grade 1-3a who are treated with currently available therapies in the real-world setting according to Lugano classification (Cheson, 2014) of malignant lymphoma and as assessed by independent central review. Secondary Objectives: To evaluate the following outcomes in adult patients with r/r FL grade 1-3a who are treated with currently available systemic therapies in the real-world setting: 1. Objective response rate (ORR) according to the Lugano classification and as assessed by treating physician evaluation 2. Complete response (CR) rate according to the Lugano classification and as assessed by: * Independent central review, and * Treating physician evaluation 3. Progression-free survival (PFS) according to the Lugano classification and as assessed by: * Independent central review, and * Treating physician evaluation 4. Overall survival (OS) 5. Duration of response (DOR) according to the Lugano classification and as assessed by: * Independent central review, and * Treating physician evaluation 6. Disease control rate (DCR) according to the Lugano classification and as assessed by: * Independent central review, and * Treating physician evaluation 7. Time to next treatment (TTNT) 8. Histological transformation (HT)
Study Type
OBSERVATIONAL
Enrollment
247
No study treatment will be administered on this study.
Regeneron Research Facility
Graz, Austria
Regeneron Research Facility
Caen, France
Regeneron Research Facility
Paris, France
Regeneron Research Facility
Pierre-Bénite, France
Regeneron Research Facility
Essen, Germany
Regeneron Research Facility
Frankfurt, Germany
Regeneron Research Facility
London, United Kingdom
Regeneron Research Facility
Manchester, United Kingdom
Regeneron Research Facility
Nottingham, United Kingdom
Objective response rate
The proportion of best overall response of complete response (CR) or partial response (PR).
Time frame: Up to 84 months
Complete Response (CR) rate
The proportion of patients with a CR after initiation of the selected line of therapy (LoT).
Time frame: Up to 84 months
Progression Free Survival (PFS)
The time from the start date of the selected LoT until the first date of progressive disease (PD) or death due to any cause, whichever occurs first.
Time frame: Up to 84 months
Overall Survival (OS)
The time from the start date of the selected LoT until death due to any cause.
Time frame: Up to 84 months
Duration of Response (DOR)
The time from the date of the first documented CR or PR until the first date of PD or death due to any cause, whichever occurs first.
Time frame: Up to 84 months
Disease Control Rate (DCR)
The proportion of patients who achieve a best overall response of CR, PR, or stable disease (SD).
Time frame: Up to 84 months
Time to Next Treatment (TTNT)
The time from the start date of the selected LoT to the start of a new antineoplastic treatment line.
Time frame: Up to 84 months
Histological transformation (HT)
The proportion of patients with evidence of HT \[ie, evolution to a clinically aggressive non-Hodgkin lymphoma such as Diffuse large B-cell lymphoma (DLBCL)\].
Time frame: Up to 84 months
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