Cardiovascular and respiratory diseases are the first and third cause of death, respectively. Cardiovascular risk is known to increase in groups with impaired lung function; however, the mechanisms behind this association are not fully understood. The aim of CaReS is to elucidate the shared pathophysiology of impaired lung function and cardiovascular risk, and to investigate the risk factors associated with them. The CaReS Cohort Study includes adults (18-80 years old) from Cartagena de Indias, a tropical city on Colombian Caribbean Coast, where recent population admixture settled a three-hybrid genetic structure (European, African and Ameridian ancestry). At baseline, the cohort will generate extensive data on -omics (e.g., genomics, transcriptomics, metabolomics, and epigenomics), socio-economic wellbeing, lifestyle, medical history, cardiometabolic, inflammatory and liver function markers, as well as objective measures of ventilatory and cardiovascular performance. The cohort will collect data every three years, for a total period of ten years. Prospective risk of cardiovascular disease and chronic obstructive pulmonary disease (COPD) will be investigated, and their risk factors. Throughout the study period, changes in prevalence, and interactions of various risk factors with these changes will also be ascertained. A predictive risk score for cardiovascular and chronic respiratory disability will be built, using cross-sectional and longitudinal data.
Study Type
OBSERVATIONAL
Enrollment
619
Exposure: Genetic predisposition to complex diseases.
Exposure: dietary intake of unhealthy foods known to be associated with higher prevalence of respiratory and cardiovascular diseases.
Exposure: frequency of moderated or intense physical activity, and daily exposure to sedentary behavior.
Exposure: socio-economic vulnerability indexes associated with higher prevalence of respiratory and cardiovascular diseases (including household conditions, accessibility to health care services, among others).
Universidad de Cartagena
Cartagena, Departamento de Bolívar, Colombia
Atherosclerosis
Carotid atheroma identified by eco-doppler imaging test
Time frame: baseline - 10 years (end of follow up)
Acute cardiovascular event
Record of acute coronary heart disease, miocardipathy, and ischemic or hemorragic cerebrovascular event.
Time frame: 2nd year (first follow up) - 10 years (end of follow up)
Chronic airflow obstruction
Obstruction patterns in post-bronchodilator spirometry.
Time frame: baseline - 10 years (end of follow up)
Metabolic syndrome
Pathologic findings for blood pressure, triglycerides, HDLc, serum glucose, and/or enlarged waist circumference (three or more of this criteria found simultaneously)
Time frame: baseline - 10 years (end of follow up)
Chronic Obstructive Pulmonary Disease (COPD)
Diagnosis of by lung function test (post-bronchodilator spirometry) and/or clinical criteria
Time frame: baseline - 10 years (end of follow up)
Hypertension
Primary high blood pressure according to clinical criteria
Time frame: baseline - 10 years (end of follow up)
Type 2 Diabetes Mellitus
Abnormal results in fasting serum glucose test and/or HbA1c test.
Time frame: baseline - 10 years (end of follow up)
Dyslipidemia
High serum cholesterol, triglycerides or LDLc; and/or low HDLc
Time frame: baseline - 10 years (end of follow up)
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