Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with acute aortic syndrome (AAS). Therefore, the prevention of SIRS and MODS is of great clinical value, and immunomodulatory therapy with thymosin alpha 1 may be beneficial. This study was designed to test the hypothesis that the administration of thymosin alpha 1 during the acute phase of AAS will result in a reduced incidence of SIRS and MODS.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
330
Thymosin alpha 1, 1.6mg injection hypodermic (I.H), every 12 hours for 5 days at least during the ICU admission. The administration will be terminated any day during the treatment when the patient is deemed as qualified for ICU discharge or dead.
Blank control
The First Affiliated Hospital of Bengbu Medical College
Bengbu, Anhui, China
RECRUITINGGuangdong Provincial People's Hospital
Guangzhou, Guangdong, China
RECRUITINGThe First Affiliated Hospital of Nanjing Medical University
Nanjing, Jiangsu, China
RECRUITINGNanjing First Hospital Nanjing Medical University
Nanjing, Jiangsu, China
RECRUITINGSubei People's Hospital of Jiangsu Province
Yangzhou, Jiangsu, China
RECRUITINGQilu Hospital of Shandong University
Jinan, Shandong, China
RECRUITINGWest China Hospital of Sichuan University
Chengdu, Sichuan, China
RECRUITINGThe Friendship Hospital of Yili Kazak Autonomous Prefecture
Kazak, Xinjiang, China
RECRUITINGThe Seventh Affiliated Hospital of Xinjiang Medical University
Ürümqi, Xinjiang, China
RECRUITINGThe First Affiliated Hospital of Kunming Medical University
Kunming, Yunnan, China
RECRUITING...and 5 more locations
The highest Sequential Organ Failure Assessment (SOFA) score of 7 days after surgery
The occurrence of new-onset organ failure and new-onset persistent organ failure (Sequential Organ Failure Assessment (SOFA) score. New-onset is defined as events that occur after randomization and not present 24 hours before randomization.
Time frame: 7 days after surgery
30-day mortality
Death from any cause of 30 days after randomization
Time frame: 30 days after randomization
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