Relationship Between Liver Cancer and Sarcopenia

First Affiliated Hospital of Wenzhou Medical University1,200 enrolled

Overview

By tracking the short-term and long-term results of patients after hepatectomy, the difference of short-term results between patients with sarcopenia and patients without sarcopenia was analyzed, and the correlation between sarcopenia and short-term and long-term results of patients after hepatectomy was explored, so as to improve people's awareness of sarcopenia and pay attention to its prevention and treatment.

All implementation details are based on the newest EWGSOP definition. The investigators consecutively admitted patients the questionnaire and evaluated the assessment of muscle strength (grip strength test and chair stand test), muscle quantity (L3 plane total skeletal muscle area) and physical performance (gait test) following the F-A-C-S approach, to confirm patients with sarcopenia accurately. And by tracking the short-term and long-term outcomes of patients after hepatectomy, the differences were analyzed and the relationship between sarcopenia and liver cancer was explored.

Study Type

OBSERVATIONAL

Enrollment

1,200

Conditions

Liver Cancer Sarcopenia

Interventions

gait speed; ct scan;grip strength and chair stand testDIAGNOSTIC_TEST

The chair stand test was administered, and the time required for the patient to stand five times from a sitting position without using the arms was measured. CT scan was to scan the patient's third lumbar level. For the gait speed test, the time that patients spent walking 8 meters on a flat indoor floor at usual walking speed was measured.Grip strength test:the dominant hand and the nondominant hand were measured twice intermittently (kg), and the average value of 4 values was obtained.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with preoperative clinical diagnosis of liver cancer * No cancer other than liver cancer has been diagnosed * Age ≥18 years Exclusion Criteria: * Patients who could not complete the standard tests and questionnaires * Patients who did not accept liver resection after evaluation of treatment plan * Patients who had other concomitant preoperative causes of muscle weakness (injury, fracture, stroke, etc.) * Patients who missing CT data or CT scan did not reach the level of the third lumbar vertebra (L3)

Locations (1)

Gang Chen

Wenzhou, Zhejiang, China

Outcomes

Primary Outcomes

Short-term postoperative results

Postoperative complications；90 days readmission rate

Time frame: 3 months

Long-term results after operation

Overall survival; Disease free survival

Time frame: 10 years

Secondary Outcomes

Postoperative hospitalization time

Time window from the day of operation to the day of discharge.

Time frame: 2 months

Hospitalization expenses

All hospitalization expenses, including drug expenses, operation expenses, anesthesia expenses, nursing expenses and other expenses.

Time frame: 2 months

Data from ClinicalTrials.gov

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