Evaluation of Respiratory Function and Functional Capacity in Pediatric Patients With Chronic Kidney Disease (CKD)

Acibadem University30 enrolled

Overview

Chronic kidney disease (CKD) is defined as a permanent abnormality in kidney structure or function that persists for more than 3 months (for example, glomerular filtration rate \[GFR\] \<60 mL/min/1.73 m2 or albuminuria ≥30 mg/24 hours) and, it effects the 8% to 16% of the population worldwide.In pediatric patients with CKD, exercise capacity begins to decline in stage 3 of the disease and progressively decreases in stage 5, in dialysis and transplant patients (4, 5). Reduction in respiratory muscle strength and six minute walk test (6MWT) is observed in patients with CKD treated with hemodialysis (HD).The aim in present study is to evaluate the relationship between functional capacity and respiratory functions in stage 1-5 pediatric chronic kidney disease patients.

The aim of this study is to evaluate functional capacity with six minutes walk test (6MWT), respiratory functions with spirometer and the correlation between functional capacity and respiratory functions in pediatric CKD patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Kidney Diseases Chronic Renal Disease Chronic Renal Failure

Interventions

Eligibility

Sex: ALLMin age: 5 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Being between the ages of 5-18, having stage I-V chronic kidney disease, * Having chronic kidney disease for at least 6 months, * Not having visual and hearing impairment Exclusion Criteria: Presence of mental retardation, * Insufficient Turkish communication, Inability to communicate, * Having metabolic-neurological problems, * Presence of cardiomyopathy, angina pectoris, * Presence of orthopedic problem that will prevent standing and walking * Cerebrovascular disease * Patients will not be included in the study in the presence of metastatic carcinoma.

Outcomes

Primary Outcomes

6 minute walk test

its a submaximal exercise test. The 6MWT is carried out in a marked 30 meter corridor. Patients are asked to walk as quickly as possible. They can stop whenever they want. The distance walked is recorded in meters. And it is interpreted according to the reference values of healthy children.quicly as possible and the distance will be record in meter.

Time frame: during the procedure

Secondary Outcomes

pulmonary function test

FVC, FEV1, FEV1/FVC, PEF parameters will be eveluated.Patients sit with a clip on their noses. After 3 technically appropriate tests, the best measured values are recorded and compared against reference values.The measurements obtained are recorded as a percentage relative to their ratio to the expected reference values.FEV1, FVC,PEF measurements are recorded as a volume in ml.