Successful embryo implantation is complicated process that requires synchrony between good-quality embryos and receptive endometrium. Human chorionic gonadotropin (hCG), is one of the initial embryonic signals and the major embryoendometrial relationship regulator. This study will be conducted to to investigate the role of parenteral hCG used for the transfer of cryopreserved- thawed embryos with HRT cycles in the outcome of artificially prepared frozen embryo transfer (FET) cycles.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
180
From the 12th to 13th day of the cycle when endometrium reached the optimal thickness ≥8 mm, group 1 (hCG) will receive 10.000 IU hCG intramuscular injection in the morning then vaginal suppository progesterone 400 mg twice a day will be started in the afternoon
Alexandria university
Alexandria, Egypt
Live birth delivery rate (LBR)
Number of live births beyond 28 weeks of gestational age to the total number of FET cycles
Time frame: 7 months
Clinical pregnancy rate
number of cases with observed gestational sac with embryonic heartbeat detected by ultrasound two weeks after positive pregnancy to the totoal number of frozen embryo transfer cycles.
Time frame: 2 weeks after positive pregnancy test
Implantation rate
proportion of the number of gestational sacs to the number of embryos transferred
Time frame: 2 weeks after positive pregnancy test
Miscarriage rate
number of lost before the 20th week of gestation to the number of clinical pregnancies
Time frame: 20 weeks gestational age
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