Patientheque in Patients With a Psychosis .

University Hospital, Brest250 enrolled

Overview

Establishment of a patient library for patients who have had a first psychotic episode and who have an "at risk" status for psychotic disorder (GRD, APS, BLIPS group) or a psychosis threshold during CAARMS administration. Samples are taken on inclusion, at 2 years, and if relapse or significant clinical event within 5 years of inclusion, on 250 patients for 10 years.

The constitution of this patient library will include results of clinical tests carried out in current practice, neurocognitive tests, blood samples, audio recordings, clinical follow-up, urine samples, fecal samples, brain imaging, EEG.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

250

Conditions

Schizophrenia Prodromal Schizophrenia, Childhood Schizophrenia

Interventions

Blood samples (36 mL) + fecal samples + hair sampleOTHER

Blood samples at inclusion, 2 years later and/or if relapse, fecal samples at inclusion and every years for 5 years, hair sample at inclusion

Eligibility

Sex: ALLMin age: 15 YearsMax age: 30 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Major and or minor aged 15 to 30 assessed within the CEVUP (Consultation for the Assessment of Psychological Vulnerability) and cared for at the psychiatry center as part of a first psychotic episode (Diagnosis CIM 10: F20 -F29 first hospitalization). These patients are referred by care and medico-social partners (general practitioners, school doctors, school nurses, educators, addictologists, psychiatrists * "At risk" status for psychotic disorder (GRD, APS, BLIPS group) or psychosis threshold during the CAARMS test (psychometric scale for the assessment of psychotic symptoms) * Consent of the patient or his legal guardian Exclusion Criteria: * History of psychosis for more than one year * "Not at risk" status for psychotic disorder on the CAARMS (psychometric scale for the assessment of psychotic symptomatology) * IQ\<70 (WAIS) * Neurological disorder or other health problem that may explain the disorders * Refusal to participate - History of psychosis for more than one year

Locations (1)

Chu Brest

Brest, France

RECRUITING

Outcomes

Primary Outcomes

CAARMS (Comprehensive assessment of at-risk mental states) score.

The test will determine the mental state of the patient : * "Not at risk of psychosis" * "At risk of psychosis" * "Psychosis threshold exceeded" It is organized into 7 clinical dimensions: 1) positive symptoms 2) cognitive changes: attention / concentration 3) emotional disturbance 4) negative symptoms 5) behavioral change 6) physical and motor changes 7) general psychopathology. Each category is scored between 0 and 6 depending on the level of intensity, frequency and duration of each symptom. In order to determine if a subject meets the UHR criteria for CAARMS, only the first category (positive symptoms) and its four subscales are used according to a scoring algorithm.

Time frame: 5 years

Secondary Outcomes

CAARMS sub-assemblies

If the patient is classified at risk of psychosis, the test will classify this risk into one of the three following categories : trait and state risk factor group, APS (attenuated psychotic symptoms) group, BLIPS (Brief, Limited or Intermittent Psychotic Symptoms) group.

Time frame: 5 years

Central Contacts

Michel WALTER

CONTACT

+332 98 01 51 56 michel.walter@chu-brest.fr

Christophe LEMEY

CONTACT

+336 19 21 10 32 christophe.lemey@chu-brest.fr

Data from ClinicalTrials.gov

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