The prevalence of allergy to legumes is inscreasing, especially in children and for some of these legumes, little is known and there are not included in the list of priority allergen. The overall goal of this study is to improve knowledge about fenugreek allergy. The principal aim is to evaluate the prevalence of allergy to fenugreek confirmed by a positive oral food challenge in children sensitized to fenugreek. The secondary objectives are to describe the case of allergy to fenugreek (co-allergies, severity, age..), to evaluate diagnostic values of skin prick-tests and specific IgE and to compare the molecular profile of specific IgE to peanut between sensitization to fenugreek without allergy and sensitization with a confirmed allergy
Study Type
OBSERVATIONAL
Enrollment
50
diagnostic values of skin prick test and specific IgE for allergy confirmed by oral food challenge (routine, not an intervention)
Centre Hospitalo-Universitaire de Nancy
Vandœuvre-lès-Nancy, France
Oral food challenge to fenugreek
Astier's score 0 to 4 (0=negative, 1 and 2=mild to moderate reaction, 3 and 4 = severe reaction)
Time frame: 2017-2022
skin prick-test to fenugreek
skin prick test positive if wheal size superior to 3mm
Time frame: 2017-2022
specific IgE to fenugreek
specific IgE positive if value superior to 0.35kU/L
Time frame: 2017-2022
severity of allergy
reactogenic dose (from 1 to 1000mg of fenugreek)
Time frame: 2017-2022
molecular profile for peanut allergy
IgE values for rAra h1, h2, h3, h6, h8, h9
Time frame: 2017-2022
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