Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS.

Central Hospital, Nancy, France122 enrolled

Overview

Mortality of patients with COVID-19 associated acute respiratory distress syndrome (CARDS) treated with veno-venous extra-corporal membrane oxygenation (vv-ECMO) is increasing over time since the beginning of the COVID-19 pandemic. The objectives were to retrospectively describe over the first ten days after vv-ECMO implantation, the ventilatory management of CARDS and to assess the impact of static respiratory system compliance (CRS) on the first day of vv-ECMO on 180-day mortality.

Study Type

OBSERVATIONAL

Enrollment

122

Conditions

Ards Mechanical Ventilation Pressure High Extracorporeal Membrane Oxygenation

Interventions

No applicableOTHER

No applicable

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with ARDS secondary to COVID-19 pneumonia requiring ECMO-VV support, hospitalized in the intensive care units of the CHRU of Nancy, Marseille or Bordeaux between 01/03/2020 and 31/12/2021. * Age \> 18 years old Exclusion Criteria: * Respiratory parameters not available on ten first day of VV ECMO implantation. * Patient refusal to participate in the study

Outcomes

Primary Outcomes

Vital status (dead or alive)

according to compliance during the first ten days of VV ECMO implantation

Time frame: Days, 10.

Secondary Outcomes

Evolution of driving pressure

after VV-ECMO implantation

Time frame: Days, 10

Evolution of tidal volume

after VV-ECMO implantation

Time frame: Days, 10

Evolution of PEEP

after VV-ECMO implantation

Time frame: days, 10

Prognostic Value of Respiratory System Compliance Under VV-ECMO on 180-day Mortality in COVID-19 ARDS.

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes