Background and Objectives: Seizure attack is one of adverse effects of vaccination in epileptic patients, the risk of which after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inoculation was elucidated in the present study. Methods: A self-controlled case series study was designed to examine the association between vaccination and epileptic seizure. A total of 240 epilepsy patients were included who were vaccinated with inactive SARS-CoV-2 vaccines (Sinovac Life Sciences and Lanzhou Institute of Biological Products) and admitted to outpatient clinics from July 2021 to December 2021. Poisson analysis was performed to estimate the relative incidence rate of epileptic seizure in risk periods (day 1-7, 8-21 and 1-21 after first-dose vaccination) compared to basal level in control period.
Study Type
OBSERVATIONAL
Enrollment
240
We included epilepsy patients who were vaccinated with inactive SARS-CoV-2 vaccines
Xijing Hospital
Xi'an, Shaanxi, China
Risk of epileptic seizures within 21 days after first-dose vaccination with inactive SARS-CoV-2 vaccine in epilepsy patients
Overall relative incidence of epileptic seizures in risk periods compared to control period.
Time frame: from 90 days before until 21 days after the first dose of vaccine
Risk of epileptic seizures in epilepsy patients of different subgroups
The associations of sex, age or medication status with the relative incidence in risk periods
Time frame: from 90 days before until 21 days after the first dose of vaccine
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