Gemeprost Versus Dinoprostone in First Trimester Miscarriages

National University of Malaysia101 enrolled

Overview

Comparison between gemeprost and dinoprostone to evacuate first trimester miscarriages.

Women who are diagnosed with first trimester missed miscarriages are invited to participate in the study. They will be randomised to either gemeprost or dinoprostone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

101

Conditions

Missed Abortion Medical; Abortion, Fetus Incomplete Abortion

Interventions

Gemeprost 1 Mg Vaginal PessaryDRUG

Intravaginal gemeprost 1 mg inserted 3 hourly for maximum of 5 doses in 24 hours

Dinoprostone 3 mgDRUG

Intravaginal dinoprostone 3 mg inserted 4 hourly for maximum of 3 doses in 24 hours

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * missed miscarriages * incomplete miscarriages * first trimester Exclusion Criteria: * coagulopathy * Rhesus negative * suspected ectopic pregnancy or pregnancy of unknown location * on anticoagulation drug * septic miscarriages * hemodynamically unstable

Locations (2)

UKM Medical Center

Kuala Lumpur, W.Persekutuan, Malaysia

UKM Medical Centre

Kuala Lumpur, W.Persekutuan, Malaysia

Outcomes

Primary Outcomes

Percentage of women who achieved complete evacuation

Complete expulsion of product of conception

Time frame: from recruitment until up to one week after commencement of treatment

Secondary Outcomes

Percentage of women who experienced side effects

side effects towards each drug such as fever, gastrointestinal upset

Time frame: from recruitment until up to one week after commencement of treatment

Data from ClinicalTrials.gov

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