This study aims to discover, verify and evaluate the potential biomarkers with regard to the diagnosis, prognostic and/or prediction of diabetic chronic wounds.
Investigators will conduct a multicenter prospective case control study consisting of three stages. In the first stage, investigators will collect clinical data and blood, urine and stool samples from diabetic patients with chronic wound (CWD), diabetic patient without newly identified wound (NWD) and patients without diabetes (ND to discover the candidate bioindicator with differences through combined high-throughput non targeted detection. In the second stage, investigators will expand the sample size and collect the clinical data and biological samples (blood, urine and stool) of the CWD,NWD and ND participants to verify the difference of the candidate bioindicator in the first stage by targeted technologies. In the third stage, investigators will collect the clinical data and biological samples (blood, urine and stool) of the CWD and NWD participants to evaluate the value of these candidate bioindicators as biomarkers.
Study Type
OBSERVATIONAL
Enrollment
930
collect whole blood, urine and stool samples
The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital
Jinan, Shandong, China
RECRUITINGBioindicators with differences among groups
Analysis omics results and discover candidate bioindicators that differ between groups
Time frame: Through study completion, an average of 1 year
Basic clinical and demographic information of participants in groups
Collect basic clinical and demographic information of participants in groups by a CRF
Time frame: Through study completion, an average of 1 year
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