Safety and Efficacy of Spinous Balloon Dilatation Catheter in CAD Treatment

Inclusion Criteria: * 1\. 18-75 years * 2.Stable or unstable angina, or previous myocardial infarction, or Asymptomatic ischemia judged by clinician ,Target vascular diameter: 2.00-4.00mm ,Coronary artery stenosis stenosis ≥ 70% by visual inspection, or ≥ 50% with evidence of ischemia, TIMI blood flow≥ 1,the operator judge that the patient needs spinous balloon to treat. * 3\. Paticipant can understand the study ,voluntarily participate in and sign the informed consent form,and accept scheduled follow-up. Exclusion Criteria: Patient related: * 1.Pregnant and breast-feeding women or intention to be pregnant. * 2.Subjects with MI within one week, or more than one week after the onset of MI,but TNI or TNT have not returned to normal. * 3.The spinous balloon failed to pass through the stenosis after small balloon dilation , and the lesion need to be rotary grinded. * 4\. Non-target vessel did not be dealed with successful before dealing with target vessel, or non-target vascular lesion number is more than three. * 5.Serious heart failure（NYHA IV） * 6.Severe renal failure（Cr\>443uMol/L) or patients undergoing hemodialysis. * 7.Patient with heart transplant. * 8.Patient with CABG. * 9.Patients with hemodynamic instability or shock symptoms. * 10.Life expectancy less than one year. * 11.Expected to undergo surgery within one month. * 12.Patients with bleeding tendency, history of active gastrointestinal ulcer, contraindications of antiplatelet or anticoagulant treatment, cannot receive anticoagulant treatment, and patients have hemorrhagic stroke within six months. * 13.Allergy to heparin and contrast agent. * 14.The illness of the patient make the treatment and evaluation difficult. * 15.Those who have participated in other drug or medical device trials have not reached main research endpoint. * 16.Clinicians estimated that the risk of intervention is very high or the patient should be excluded for other reasons. * 17.Poor of compliance Lesion related: * 18.Lesions of LAD or with a distance of ≤ 2mm beyond LAD. * 19.Angiogram showed thrombus. * 20.CTO,and TIMI blood flow=0, * 21.Coronary artery spasm * 22.Lesions of LAD without bypass surgery or collateral circulation protection. * 23.The doctor considered the patient unfit for the trial.