Biological & Fonctional Signatures for Muscle Failures, Aged People & Personalized Physical Activity

Centre Hospitalier Universitaire de Nice900 enrolled

Overview

Physical activity is one of the most effective therapeutic interventions for frailty, sarcopenia or dynapenia. The benefits of physical activity processes are already widely documented. Typically, researchers want to understand the average response to an intervention to determine its overall effectiveness. However, sports trainers have understood it for a long time, the response of an athlete or a patient to training is very variable and the standard deviations present in all the scientific studies on the subject confirm it. There is therefore inter-individual variation in the response to exercise, with some subjects showing much greater improvements than others. Thus, one can wonder if this "non-response" following training is specific to the training modality. The effects of physical exercise on the body depend mainly on its type, intensity and duration. Thus, from a practical point of view, the most important perspective is the prediction and, ultimately, the individual optimization of management through physical activity.

Main objective: To determine the effects of personalized physical activity management on the biological signatures of muscle failure. Secondary objectives: * Propose a support system through adapted and individualized physical activity, based on physical, biological and psycho-social indicators * Identify the biological signatures (metabolomics, epigenetic) of muscle failure in the elderly. Phenotype responders and non-responders in training 900 seniors (300 per group) APAP group: adapted and personalized physical activity APA group: adapted physical activity Control group: no physical activity Total duration of the study 5 years, duration of participation for a patient 3 months; inclusion period: 57 months Improvement of muscle failure in its broad definition (Strength, power, speed and lean mass) ) General data: description of characteristics with frequencies and percentage for categorical variables and with mean and standard deviation for quantitative variables. ii) Analysis of the primary endpoint: Machine Learning (or supervised classification) and signaling pathway prediction approaches for statistical analysis and data interpretation. iii) Analysis of secondary judgment criteria: approaches in Machine Learning (or supervised classification) and signaling pathway prediction for statistical analysis and interpretation of data with comparison of quantitative variables by Pearson correlation and categorical variables by t or chi 2 test depending on the case. Adapt and individualize physical activity support for healthy or frail elderly people

Study Type

INTERVENTIONAL

Interventions

blood samplePROCEDURE

blood sample before and after 12 weeks of physical activity

physical assessementOTHER

physical assessement before and after 12 weeks of physical activity * Standardized geriatric assessment (physician visit) * ICOPE Monitor Assessment * Sit-to-stand Test * Quantified Gait Analysis (QAM) * Bone densitometer measurement of body composition

psychometric assessmentBEHAVIORAL

Psychometric questionnaires * Cognitive tests (MMSE) * The long questionnaire of personality traits: Big Five Inventory * Perceived health and subjective age * Age group identification * Attitudes towards aging: French version of the Attitudes Toward Own Aging scale * Physical self-perception: French version of the Physical Self-Perception Profile * MOTIVATION SCALE FOR PA FOR HEALTH PURPOSES: Motivation Scale for Physical Activity in a Health Context * Aging Stereotypes and Exercise Scale

Eligibility

Sex: ALLMin age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age greater than or equal to 60 years * Affiliated patient or beneficiary of a social security scheme * Patient having signed a prior informed consent. Exclusion criteria * Neurocognitive disorder preventing the expression of informed consent * Patients protected by law under guardianship or curatorship, or who cannot participate in a clinical study under Article L. 1121-16 of the French Public Health Code * Presence of a physical or cognitive pathology preventing the performance of the adapted physical activity protocol over 3 months.

Outcomes

Primary Outcomes

muscle power

muscle power (Watt/Kg) assessed with the isokinetic ergometer.

Time frame: before and after 12 week of physical activity program

Secondary Outcomes

Different metabolomic signature (The amino acid composition) between the groups (APA, APAP, no physical activity)

Change in the amino acid composition (metabolomic signature) at Day 0 between the groups

Time frame: at day 0

Change in the amino acid composition (metabolomic signature) after 3 month of physical activity

Change in the amino acid composition (metabolomic signature) after 3 month of physical activity for the APA and APAP groups compared to the no physical activity group

Time frame: between Day 0 and Month 3

ICOPE Monitor Assessment

Score of frailty. (Implementation of the Integrated Care of Older People, ICOPmonitor, 8 item, higher score means worse outcome)

Time frame: before and after 12 week of physical activity program

Sit-to-stand Test

number of movement

Time frame: before and after 12 week of physical activity program

Quantified Gait Analysis (QAM)

Gait velocity in m.s-1

Time frame: before and after 12 week of physical activity program

Bone densitometer measurement of body composition

% of lean mass

Time frame: before and after 12 week of physical activity program

Cognitive tests

Score Mini-Mental State Examination (MMSE, 0-30, higher score mean worse outcome)

Time frame: before and after 12 week of physical activity program

The long questionnaire of personality traits

Score of Big Five Inventory, 0-44, higher score means worse outcome

Time frame: before and after 12 week of physical activity program

Perceived health (Score of the scale)

Score of the scale, 0-6, higher score means better outcome

Time frame: before and after 12 week of physical activity program

Subjective age

Subjective age in years

Time frame: before and after 12 week of physical activity program

Age group identification (Years)

Age group identification in years

Time frame: before and after 12 week of physical activity program

Attitudes towards aging

Score on the French version of the Attitudes Toward Own Aging scales, 0-7, higher score means better outcome

Time frame: before and after 12 week of physical activity program

Physical self-perception

Score on the French version of the Physical Self-Perception Profile, 0-6, higher score means better outcome

Time frame: before and after 12 week of physical activity program

Motivation scale for physical activity for health purposes

Score on the Motivation Scale for Physical Activity in a Health Context,0-30, higher score means better outcome

Time frame: before and after 12 week of physical activity program

Aging Stereotypes and Exercise Scale

Score on the French Aging Stereotypes and Exercise Scale (ASES), 0-12, higher score means better outcome

Time frame: before and after 12 week of physical activity program

Improvement of muscle force

Improvement of muscle force (N/Kg) assessed with the isokinetic ergometer.

Time frame: before and after 12 week of physical activity program

Biological & Fonctional Signatures for Muscle Failures, Aged People & Personalized Physical Activity

Overview

Conditions

Interventions

Eligibility

Locations (1)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts