Efficacy of Median Nerve Hydrodissection by Hyalase Versus Midazolam in the Treatment of Carpal Tunnel Syndrome:

Early Phase 1UnknownNCT05344495

Minia University100 enrolled

Overview

Comparing efficacy of hyalase and midazolam in median nerve entrapement neuropathy

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

100

Conditions

Pain, Neuropathic

Interventions

hyalase groupDRUG

bupivacaine 15 mg 0.5% plus 2 mL normal saline containing 300 international units (IU) hyaluronidase.

midazolam groupDRUG

2 mg midazolam dissolved in 2 ml sterile saline plus 15 mg bupivacaine 0.5%

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients (30 - 70 years old) complaining of carpal tunnel syndrome of 3 month duration or more , diagnosed axonal neuropathy using electrodiagnosis , nerve conduction study refractory to medical treatment for 2 months . Exclusion Criteria: * Diabetic patients * Pregnant population . * Refusal to participate

Locations (1)

Mina Raouf

ALMinya, Minya Governorate, Egypt

RECRUITING

Outcomes

Primary Outcomes

pain score

visual analogue score which represents 0 = no pain, 10= worst un-imaginable pain

Time frame: 6 months

Secondary Outcomes

Boston questionnaire

symptom severity ... function severity

Time frame: 6 months

median nerve sonogrphy

cross sectional area

Time frame: 6 months

Nerve electrophysiology

sensory velocity and distal motor latency ... 1m/sec is the least and 10m/sec is the highest

Time frame: 6 months

Data from ClinicalTrials.gov

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