A case-control study to assess the association between the risk of diabetic retinopathy in Egyptians and genetic polymorphism of both EPO and SLMAP genes.
Traditional environmental risk factors, such as glycemic control and duration of diabetes, failed to fully explain why some individuals remain protected while others progress to severe diabetic retinopathy. Several studies suggest variations in diabetic retinopathy prevalence depending on racial background and genetic polymorphism.
Study Type
OBSERVATIONAL
Enrollment
180
Presence of EPO gene SNP rs551238 and SLMAP rs17058639 gene polymorphisms
Ain Shams University Hospitals
Cairo, Abbasseya, Egypt
Association of SLMAP gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis
the odds ratio of being diagnosed with diabetic retinopathy in those with SLMAP rs17058639 single nucleotide polymorphism compared to wild type
Time frame: At baseline (upon confirmed diagnosis of diabetic retinopathy)
Association of EPO gene polymorphism and the risk of confirmed diabetic retinopathy diagnosis
The odds ratio of being diagnosed with diabetic retinopathy in those with EPO rs551238 single nucleotide polymorphism compared to wild type
Time frame: At baseline (upon confirmed diagnosis of diabetic retinopathy)
The association of confounding factors on the incidence of diabetic retinopathy
A multiple logistic regression model will be fitted to assess the association of diabetic retinopathy to confounders (microalbuminuria, lipid profile, age, gender,...etc.)
Time frame: At baseline
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