Colchicine Effect on Perivascular Inflammation Index on Coronary CTA

Inclusion Criteria: * Individuals of both sexes over 18 years of age; * Patients undergoing coronary CT angiography from May/2021 * CT angiography showing non-calcified or mixed coronary plaques and high FAI value (\> -70.1 HU) in the proximal segment of the right and/or anterior descending coronary artery with * Willing and able (in the opinion of the investigators) to fulfill all study requirements Exclusion Criteria: * Past history of acute myocardial infarction * History of percutaneous or surgical myocardial revascularization * History of previous cardiac surgery or congenital heart disease * Current use of colchicine * Autoimmune disease requiring immunosuppressive therapy or current use of systemic corticosteroid therapy * Active neoplasm with indication of surgery, chemotherapy or radiation in the last 12 months (patients with a history of neoplasm and who underwent curative surgery without need for treatment in the last 12 months will be allowed) * Inflammatory bowel disease or chronic diarrhea * Clinically significant non-transient hematologic abnormalities * Renal dysfunction (GFR \< 30 mL/min/1.73 m² and/or serum creatinine \> 2.5 mg/dL or \< 220 µmol/l) * Severe liver disease (aspartate aminotransferase \[AST\] or alanine aminotransferase \[ALT\] \> 3x ULN in the last 6 months) * Drug addiction or alcoholism * History of clinically significant sensitivity to colchicine * Inability to sign the informed consent form * Participation in another study