Study of the Pronostic Impact of Immunohistochemical, Histological and Radiological Factors in Patients With Primary Central Nervous System Lymphoma.

Central Hospital, Nancy, France94 enrolled

Overview

Primary Central Nervous System Lymphoma (PCNSL) have a specific mutational profile in comparison to systemic diffuse large cells lymphoma (DLBCLs) that can be related to the expression of immunohistochemical markers as cyclon, NPM1, CD30, and P53 which could be predictive factor for prognosis and/or chemotherapy response. The main objective of this study is to identify new prognostic factors and new potential therapeutic targets. The secondary objectives are to correlate the histological, the radiological and the clinical's informations of these patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Rare Disease With Poor Outcome

Eligibility

Sex: ALLMin age: 21 Years

Medical Language ↔ Plain English

Inclusion Criteria: * PCNSL diagnosed between January 2011 and December 2019, without regard to the clinical outcome. * Age \> 18 Exclusion Criteria: * Systemic DLBCL

Outcomes

Primary Outcomes

correlation between the survival and the expression of Cyclon, NPM1 and CD30.

kaplan meyer

Time frame: 17/10/2022

Secondary Outcomes

the correlation between the molecular abnormalities and the expression of Cyclon, NPM1 and CD30