Hospital acquired thrombosis describes blood clots that form in the legs and lungs after someone is treated in hospital. Clots in the leg can cause swelling, pain and other problems. If a clot in the leg travels to the lungs, it may be life threatening. Having surgery increases the risk of developing blood clots. People having short-stay surgery (who either go home the same day or who stay overnight but go home shortly afterwards) are at a much lower risk of developing a blood clot than those who stay in hospital for longer. These low-risk people are often given elastic stockings (which squeeze the leg muscles) to reduce the chance of a blood clot. The risks of wearing the stockings are low but they can be uncomfortable. In the UK, there are over a million short stay surgeries performed each year and most of these people are given elastic stockings to wear. Stockings cost the NHS a lot of money and it remains unknown if they work. This study will investigate if it is worthwhile to continue using elastic stockings in people having surgery where the risk of developing blood clots is low. Adults (over 18-years) who are at low risk of developing blood clots (assessed using a nationally recognised tool) will be included.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
21,472
Centres randomised to the intervention arm will consist of participants receiving GCS.
Barnsley Hospital NHS Foundation Trust
Barnsley, United Kingdom
RECRUITINGFrimley Health NHS Foundation Trust
Camberley, United Kingdom
RECRUITINGQueen Victoria Hospital NHS Foundation Trust
East Grinstead, United Kingdom
RECRUITINGImperial College Hospital NHS Foundation Trust
London, United Kingdom
RECRUITINGSouth Tees Hospitals NHS Foundation Trust
Middlesbrough, United Kingdom
RECRUITINGThe Newcastle upon Tyne Hospitals NHS Foundation Trust
Newcastle upon Tyne, United Kingdom
RECRUITINGSherwood Forest Hospital NHS Foundation Trust
Nottingham, United Kingdom
RECRUITINGNorth Tees and Hartlepool NHS Foundation Trust
Stockton-on-Tees, United Kingdom
RECRUITINGSomerset NHS Foundation Trust
Taunton, United Kingdom
RECRUITINGThe rate of symptomatic VTE within 90 days
The rate of symptomatic VTE for surgical patients undergoing short-stay procedures assessed as being at low-risk of VTE
Time frame: 90-days
Mortality
Time frame: 90-days
Quality of Life
Quality of Life assessed using the EQ-5D
Time frame: 7 and 90-days
Adverse events related to GCS
Adverse events related to GCS for those in the intervention arm only
Time frame: 7-days
Health Economic Outcome
Incremental Cost-Effectiveness Ratio (ICER)
Time frame: 2 years
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