Efficacy of Plant-protein Diets in Patients With Chronic Kidney Disease

Osaka University40 enrolled

Overview

The purpose of this study is to evaluate the efficacy of plant-protein diets for 12 weeks in patients with advanced chronic kidney disease.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Chronic Kidney Disease Stage 5

Interventions

Plant-protein DietsOTHER

Participants will consume meals with 70% plant-based protein three times a day. Participants will be prohibited to have meals other than experimental diets and to drink milk and soy milk.

Control DietsOTHER

Participants will consume meals with 50% plant-based protein three times a day. Participants will be prohibited to have meals other than experimental diets and to drink milk and soy milk.

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. patients with chronic kidney disease who were referred to the Outpatient Department of Nephrology at Osaka University Hospital 2. eGFR \< 20 mL/min/1.73 m2 3. taking anigiotensin-converting enzyme inhibitors or angiotensin Ⅱ receptor blockers or angiotensin receptor neprilysin inhibitor 4. K \< 5.5 mEq/L Exclusion Criteria: 1. Being planned to intitate renal replacement therapies within 3 months 2. Having inflammatory bowel diseases 3. History of gastrointestinal tract surgery 4. Taking antibiotics within 1 month before the entry 5. Taking or being planned to start warfarin 6. Having dietary allergies 7. Having difficulty in oral intake 8. During pregnancy or breastfeeding 9. Unsuitable for participant in the trial by an attending physician

Locations (1)

Department of Nephrology, Osaka University

Suita, Osaka, Japan