The goal of the study is to characterize preclinical Alzheimer's Disease and related dementias (AD/ADRD) neuropathology in a selected group of young adults with youth-onset diabetes, and an age-similar group of young adults without diabetes.
The goal of the current proof-of-concept study is to characterize brain structural, functional, and molecular imaging biomarkers of preclinical Alzheimer's Disease and related dementias (AD/ADRD) neuropathology in a selected group of young adults with youth-onset diabetes (Y-DM; type 1 diabetes \[T1D\], n=5; type 2 diabetes \[T2D\], n=5) from the SEARCH for Diabetes in Youth study cohort, and an age-similar group of young adults without diabetes (n=5). This study will quantify structural and functional imaging biomarkers of AD/ADRD neuropathology via magnetic resonance imaging by assessing gray matter (GM) volume/cortical thickness, as well as GM and white matter (WM) microstructure, resting state functional network connectivity (rsfMRI), and cerebral blood flow (CBF) and WM hyperintensity volume. This study will additionally quantify brain tau density via positron emission tomography as the gold-standard measure of preclinical AD/ADRD neuropathology.
Study Type
OBSERVATIONAL
Enrollment
14
Following published manufacturer guidelines for Flutemetamol (VizamylTM), Flortaucipir (TauvidTM) and PI-2620 tracer administration162, all participants will be given a 370 MBq (10 mCi) single intravenous bolus (total volume 10mL) of the radiotracer, followed with an intravenous flush of 0.9% sodium chloride injection. Radiotracer administration and participant monitoring will be conducted by trained personnel from the CU-RIC.
Lifecourse Epidemiology of Adiposity and Diabetes Center
Aurora, Colorado, United States
Temporal lobe volume in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Voxel-based morphometry via Sagittal 3D Accelerated MPRAGE/IRSPGR
Time frame: Baseline
Temporal lobe cortical thickness in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Voxel-based morphometry via Sagittal 3D Accelerated MPRAGE/IRSPGR
Time frame: Baseline
Whole brain white matter hyperintensities volume in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Structural cerebrovascular disease via Sagittal 3D FLAIR
Time frame: Baseline
Regional homogeneity of the default mode network in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Resting-state functional connectivity via Axial T2\* EPI fcMRI
Time frame: Baseline
Whole brain cerebral blood flow in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Cerebral blood flow or perfusion via Axial 3D pCASL
Time frame: Baseline
Whole brain fractional anisotropy in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Gray matter and white matter microstructure via Diffusion Kurtosis Imaging
Time frame: Baseline
Standardized uptake value ratio for hippocampal to cerebellar comparison in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Tau accumulation via positron emission tomography with PI-2620 radiotracer
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Time frame: Baseline
Standardized uptake value ratio for entorhinal to cerebellar comparison in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Tau accumulation via positron emission tomography with PI-2620 radiotracer
Time frame: Baseline
Standardized uptake value ratio for cerebral to cerebellar comparison in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Tau accumulation via positron emission tomography with PI-2620 radiotracer
Time frame: Baseline
Whole brain gray matter volume in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Voxel-based morphometry via Sagittal 3D Accelerated MPRAGE/IRSPGR
Time frame: Baseline
Whole brain white matter volume in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Voxel-based morphometry via Sagittal 3D Accelerated MPRAGE/IRSPGR
Time frame: Baseline
Perivascular space in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Structural cerebrovascular disease via Sagittal 3D FLAIR
Time frame: Baseline
Atlas based region of interest cerebral blood flow in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Cerebral blood flow via Axial 3D pCASL
Time frame: Baseline
Atlas based region of interest fractional anisotropy in young adults with Type 1 diabetes, Type 2 diabetes, and young adults without diabetes
Gray matter and white matter microstructure via Diffusion Kurtosis Imaging
Time frame: Baseline