To research and explore the antibody protection and immune memory after vaccination in children with KHE during sirolimus administration. To explore the feasibility (safety and efficacy) of vaccination in a timely manner during the administration of sirolimus in children with KHE. To search for back-up plans for vaccination regimens for KHE patients taking sirolimus in children who do not respond to primary vaccination.
Children with KHE have an early onset. KHE usually occurs in infants and young children less than 1 year old, of which neonates account for about 38.5%-60% of all cases. Due to the immunosuppressive effect of sirolimus, the vaccination was usually suspended after taking it, and children would be in a state of no immune protection. These children are at greatly increased risk of exposure to microorganisms and consequent infection. Therefore, it is necessary to vaccinate them against infectious diseases. However, vaccination with live vaccines has the potential to cause severe infections through reversion of the vaccine strain to a pathogenic form. Moreover, studies have also shown that protective antibodies are severely affected in transplant patients taking immunosuppressive drugs and in patients with solid tumors after chemotherapy. Loss of immune memory is very common, and marked deficits in B cell function and humoral immunity can persist even for years.
Study Type
OBSERVATIONAL
Enrollment
174
Children's Hospital of Fudan University
Shanghai, Shanghai Municipality, China
RECRUITINGTiters of Hepatitis B virus surface antibody
Titers of Hepatitis B virus surface antibody，indicating whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Titers of Hepatitis B virus surface antibody
Titers of Hepatitis B virus surface antibody，indicating whether there is persistent
Time frame: The 7th month after admission
Titers of Hepatitis B virus surface antibody
Titers of Hepatitis B virus surface antibody，indicating whether there is persistent
Time frame: The 12th month after admission
Titers of Hepatitis B virus surface antibody
Titers of Hepatitis B virus surface antibody，indicating whether there is persistent
Time frame: The 18th month after admission
Levels of measles antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Levels of mumps antibodies
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Levels of rubella antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Levels of measles antibodies.
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 7th month after admission
Levels of mumps antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 7th month after admission
Levels of rubella antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 7th month after admission
Levels of measles antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 12th month after admission
Levels of mumps antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 12th month after admission
Levels of rubella antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 12th month after admission
Levels of measles antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 18th month after admission
Levels of mumps antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 18th month after admission
Levels of rubella antibodies.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 18th month after admission
Level of Japanese encephalitis antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Level of Japanese encephalitis antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 7th month after admission
Level of Japanese encephalitis antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 12th month after admission
Level of Japanese encephalitis antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 18th month after admission
Level of varicella antibody
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Level of varicella antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 7th month after admission
Level of varicella antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 12th month after admission
Level of varicella antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 18th month after admission
Level of COVID-19 antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: Admission within 1 day
Level of COVID-19 antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 7th month after admission
Level of COVID-19 antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 12th month after admission
Level of COVID-19 antibody.
This outcome indicates whether there is persistent protective antibodies after vaccination.
Time frame: The 18th month after admission