Obstructive sleep apnea (OSA) and non-alcoholic fatty liver disease (NAFLD) are both common diseases related to metabolic diseases with potential cardiovascular consequences and liver complications respectively. Though studies show OSA may take part in the progression of hepatic steatosis, the independent contribution of OSA on liver fat accumulation is unknown. It is hypothesized that nocturnal intermittent hypoxia from OSA is the main driver of NAFLD in non-obese OSA patients. This study is to assess the effect of OSA on NAFLD in non-obese patients.
Study Type
OBSERVATIONAL
Enrollment
1,000
Chinese University of Hong Kong
Hong Kong, Hong Kong
Number of subjects found to have fatty liver disease among obese patients with obstructive sleep apnea
Time frame: baseline
Number of subjects found to have fatty liver disease among non-obese patients with obstructive sleep apnea
Time frame: baseline
Number of subjects found to have fatty liver disease among obese subjects without obstructive sleep apnea
Time frame: baseline
Number of subjects found to have fatty liver disease among non-obese subjects without obstructive sleep apnea
Time frame: baseline
mesenteric fat thickness by ultrasound scan of all subjects
Time frame: baseline
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