Impact of Structural and Myelin Abnormalities on Cognitive Impairments in Recent-onset Schizophrenia - Before and After Lurasidone Treatment (MARYLU)

Inclusion Criteria for the experimental arm: * Patients diagnosed with schizophrenia with onset in the past 5 years, diagnosed through a structured clinical interview (SCID-5 CV) * Aged between 18 and 35 years * Patients requiring treatment with lurasidone (independently from the inclusion in the present study) or that are being treated with lurasidone for 2 weeks maximum. * no other psychotropic treatment during the 2 weeks preceding the beginning of the study * Acceptance of the informed consent form for the participation to the study * For women in childbearing age, negative pregnancy test (urine or blood Beta HCG) performed before the start of the treatment and use of a highly efficient contraceptive method (such as progestin contraceptives, estrogen-progestin contraceptives, IUD, IUS, bilateral fallopian tube blockage, vasectomized partner, sexual abstinence) throughout the duration of the treatment. Exclusion Criteria for the experimental arm: * presence of other psychiatric and/or neurological diagnoses * previous antipsychotic treatment, except for patients that have been treated with other antipsychotics for less than a month and that have not been treated in the two weeks preceding the beginning of the trial, who are considered eligible. * contraindications to lurasidone treatment (as per summary of product characteristics) * intellectual disability * alcool or substance abuse in the previous 6 months * presence of absolute or relative contraindications to MRI * underage patients * no negative pregnancy test or no use of a highly efficient contraceptive method * pregnancy (if a patient becomes pregnant during the course of the study, the subject will be excluded from the study) Inclusion criteria for healthy controls: * Aged between 18 and 35 years * Acceptance of the informed consent form for the participation to the study Exclusion criteria for healthy controls: * presence of psychiatric and/or neurological disorders * family history of psychiatric disorders in 1st-degree relatives * intellectual disability * other medical conditions at the time of the study * family history of hereditary neurological diseases * alcool or substance abuse * presence of absolute or relative contraindications to MRI * underage patients * no negative pregnancy test or no use of a highly efficient contraceptive method * pregnancy (if a subject becomes pregnant during the course of the study, the subject will be excluded from the study)