Effect of Tumor Micronecrosis on Postoperative Transcatheter Arterial Chemoembolization in Patients With Hepatocellular Carcinomas

Zhejiang University900 enrolled

Overview

Micronecrosis is a novel pathological feature of hepatocellular carcinoma (HCC). This study was aimed at evaluating the effect of tumor micronecrosis on postoperative transcatheter arterial chemoembolization (TACE) in patients with hepatocellular carcinomas, and further exploring the value of micronecrosis for guiding TACE in HCC management.

Study Type

OBSERVATIONAL

Enrollment

900

Conditions

Carcinoma, Hepatocellular

Interventions

transcatheter arterial chemoembolizationPROCEDURE

transcatheter arterial chemoembolization after liver resection

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * (1) pathologically confirmed HCC (2) achievement of R0 resection. Exclusion Criteria: * (1) simultaneous presence of other tumors ; (2) receipt of preoperative anti-tumoral treatments; (3) concurrent treatment with other antitumoral therapies in combination with TACE; (4) tumor necrosis that could be observed by gross examination; (5) a lack of necessary preoperative laboratory test results.

Locations (2)

the First Affiliated Hospital, School of Medicine, Zhejiang University

Hangzhou, Zhejiang, China

the First Affiliated Hospital, Zhejiang University School of Medicine

Hangzhou, Zhejiang, China

Outcomes

Primary Outcomes

overall survival

the number of months from the date of surgery to the date of the last follow-up visit or time of death.

Time frame: after liver resection until June 1, 2020

Secondary Outcomes

disease-free survival

the number of months from the date of surgery to the date of first confirmable recurrence or death

Time frame: after liver resection until June 1, 2020

Data from ClinicalTrials.gov

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