The population of these monocentric and retrospective study includes patients hospitalized in one of the critical care services of Nîmes' community hospital. The objective is to determine the key factors that lead to satisfactory beta-lactams serum concentrations in critically ill patients. Clinical and biological features, as well as risk scores are collected and recorded into an electronic Case Report Form. The primary outcome is to show the main characteristics related to adequate beta-lactams serum concentrations in critically ill inpatients. Secondary outcomes include the key factors related to inadequate beta-lactams serum concentrations in critically ill inpatients, Therapeutic Drug Monitoring (TDM) impact in the achievement of target beta-lactams serum concentration and the correlation between Aminoglycosides and Beta-lactams serum concentrations. Do both antibiotics have similar elimination kinetics ?
Study Type
OBSERVATIONAL
Enrollment
156
CHU de Nîmes - Hôpital Universitaire Carémeau
Nîmes, France
To identify factors associated with adequate beta lactam plasma concentrations on the first sample
Determinants of adequate beta-lactams plasma concentrations using a univariate, then a multivariate analysis on patients 'characteristics at baseline and on the day of TDM
Time frame: Day 7
To identify factors related with on-target beta-lactams plasma concentrations on the second sample
Risk factors of inadequate beta-lactam plasma concentrations using a univariate, then a multivariate analysis on patients 'characteristics at baseline and on the day of TDM.
Time frame: Day 7
To identify factors related with on-target beta-lactams plasma concentrations on the second sample
Proportion of on target 2nd dosing after inadequate first dosing
Time frame: Day 7
Impact of TDM
Mean number of TDM per patient with off-target first dosing and delay to achieve target plasma concentrations.
Time frame: Day 7
To assess if beta-lactams and Aminoglycosides have the same elimination kinetic
Linkage between beta-lactams and aminoglycosides' trough concentrations for patients concurrently treated by both antibiotics.
Time frame: Day 7
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