Study on Pharmacokinetics of Meperizumab Injection and NUCALA® in Healthy Male Volunteers

Inclusion Criteria: * 1 Before the study, the informed consent was signed and the content, process and possible adverse reactions of the test were fully understood; * 2 Able to complete the research according to the requirements of the test protocol; * 3 Male subjects aged 18-55 (18 and 55 included); * 4 Body weight ≥ 50 kg ≤90 kg, body mass index (BMI) ≥ 19 ≤ 26kg/m2; * 5 Health status: No mental disorders, no history of cardiovascular system, nervous system, respiratory system, digestive system, urinary system, endocrine system and metabolic abnormalities; * 6 Subjects had no pregnancy plans and voluntarily used effective contraception for at least 6 months from 2 weeks prior to self-medication to their last use of study medication. Exclusion Criteria: * 1 Previous neuropsychiatric, respiratory, cardiovascular, digestive, hemolymph, hepatic and renal dysfunction, endocrine, skeletal and musculoskeletal disorders, or other diseases that the investigator judged might affect drug metabolism or safety; * 2 Known allergy to meperizumab or its excipients; * 3 Known history of allergic disease or allergy or history of asthma disease; * 4 Prior treatment with meperizumab or an IL-5 receptor inhibitor, or other antibody or protein drugs that target the IL-5 receptor; * 5 Who received any live viral vaccines within 2 months prior to infusion of the study drug, or who needed to be vaccinated between the screening period and the end of the study, who used the study drug within 12 months prior to administration of the study drug or planned to receive any monoclonal antibodies or biologic drugs within 12 months after administration of the study drug; * 6 Patients who have unhealed wounds, ulcers or fractures, or who underwent major surgery within 3 months prior to infusion of the study drug, or who are expected to undergo major surgery within 2 months after study completion; * 7 Any prescription, over-the-counter, vitamin product or herbal medicine used in the 2 weeks prior to taking the study drug; * 8 Abnormal and clinically significant examinations during screening period; * 9 Blood donation or significant blood loss within 3 months prior to taking the study drug (\& GT; 450 ml); * 10 Participated in any drug clinical trials within 3 months prior to taking the study drug; * 11 Those who smoked more than 5 cigarettes a day 3 months before the experiment; * 12 History of alcohol abuse (14 units of alcohol per week: 1 unit =360mL beer or 45mL 40% spirits or 150mL wine); * 13 Those who are screened positive for drugs or have a history of drug abuse in the past five years or have used drugs in the three months prior to the test; * 14 Screening positive for hepatitis (including hepatitis B and C), acquired immunodeficiency syndrome(AIDS) and syphilis; * 15 The subject is unable to complete the test due to personal reasons; * 16 Conditions that other researchers consider inappropriate for inclusion