Effects of Yoga on Sodium-induced Pressor Responses in African American Adults

Texas State University15 enrolled

Overview

This investigation aims to determine the effects of a 4-week yoga intervention on sodium-induced pressor and endothelial function responses as well as markers of renal sodium handling in African American adults.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Blood Pressure

Interventions

YogaBEHAVIORAL

Yoga sessions will be completed 5 times per week for 4 weeks.

Waitlist controlBEHAVIORAL

Waitlisted participants will maintain their normal exercise and diet for 4 weeks. After follow up testing at week 4, participants will be rerandomized to the yoga condition.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * African American * Adults ages 18-60 years Exclusion Criteria: * pregnancy or within 60 days postpartum * having taken blood pressure (including diuretics beta-blockers, ACE inhibitors, angiotensin receptor blockers, and calcium channel blockers) or statin medications within the past 3 months (statins have been demonstrated to reduce oxidative stress which could impact flow-mediated dilation); * infection (viral or other) within the past 4 weeks; * having adrenal or endocrine tumors (these could impact BP); * renal disease defined as a glomerular filtration rate (GFR) of less than 60 (creatinine will be tested at initial screening and GFR will be calculated); * prior myocardial infarction; vii) known coronary heart disease; * personal history of stroke; * heart failure; * cardiac arrhythmias; * chronic obstructive pulmonary disease; * recent chest pain or dyspnea; * orthopedic limitations that preclude the execution of yoga postures; * current insulin dependence; * currently taking steroid medications; * currently undergoing chemotherapy or radiation; * having practiced yoga or yogic breathing techniques at least once weekly consistently within the past 3 months; * heat intolerance or electrolyte imbalances (hypo- or hyper-natremia or hypo- or hyper-kalemia).

Locations (1)

Cardiovascular Physiology Laboratory-Texas State University

San Marcos, Texas, United States

Outcomes

Primary Outcomes

Change in blood pressure from low- to high-sodium dietary conditions

Blood pressure will be measured after 3 days of very low sodium and 3 days of high sodium intake.

Time frame: Measurements will be completed after 3 days of low and 3 days of high sodium intake at baseline and after 4 weeks for both conditions.

Change in endothelial function from low- to high-sodium dietary conditions.

Flow-mediated dilation will be measured via ultrasound imaging of the upper arm after 3 days of low- and 3 days of high- sodium dietary conditions.

Time frame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

Change in arterial stiffness from low- to high-sodium dietary conditions.

Cardio-ankle vascular index will be measured after 3 days of low- and 3 days of high-sodium intake.

Time frame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

Secondary Outcomes

Change in urinary sodium excretion from low- to high-sodium dietary conditions.

24-hour urine collection will be completed after 3 days of low- and after 3 days of high-sodium dietary conditions.

Time frame: Measurements will be completed after 3 days of low- and 3 days of high-sodium intake at baseline and at week 4.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.