A Phase I Clinical Study on SHR6390 in Healthy Chinese Volunteers

Inclusion Criteria: * Healthy Chinese male and female aged 18-45years with a minimum weight of 50 kg for male and 45 kg for female subjects and a body mass index (BMI) of 18-26 kg/m2 who provided written informed consent for participating in the study. * Without history of cardiovascular, hepatic, kidney, pulmonary, endocrine, gastrointestinal, neurological, or psychiatric disease. * No pregnancy plan during the trial or within 6 months after completion of the trial. * Voluntarily signed the informed consent form and strictly adherence to the study protocol. Exclusion Criteria: * vital signs, physical examination, 12-lead electrocardiogram, and laboratory examination had results of clinical significance. * Hepatitis B and C, human immunodeficiency virus (HIV) and syphilis antibody positive; * Any history of allergy, alcohol and drug abuse; * blood donation, massive blood loss (≥400mL). * Participated in other clinical trials within three months. (6) Severe infection or surgery four weeks prior to screening; * use of any drug that inhibits or induces hepatic metabolizing enzymes four weeks prior to screening; * use of any prescription drugs, over-the-counter drugs, Chinese herbal medicines and health care products fourteen days prior to screening; * A history of dysphagia, gastrointestinal ulcers, or any gastrointestinal disease that interferes with drug absorption.