The purpose of this study is to investigate whether protocolized vasopressor use for patients with normal blood pressure undergoing rapid sequence intubation improves hemodynamic parameters and mitigates adverse events. The hypothesis is that use of vasopressors during Rapid Sequence Intubation will prevent substantial decreases in blood pressure when compared to normal intravenous fluids.
Aim: Prevent 25-46 percent reduction in systolic blood pressure associated with rapid sequence intubation with norepinephrine compared to isotonic fluids alone.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
42
Norepinephrine continuous infusion at 0.10 mcg/kg/min
500mL infusion run at 999mL/hr
500mL infusion run at 999mL/hr
500mL infusion run at 999mL/hr
Miami Valley Hospital Premier Health
Dayton, Ohio, United States
Systolic Blood Pressure
Change in systolic blood pressure during rapid sequence intubation in mmHg.
Time frame: 1 hour after Rapid Sequence Intubation
Change in serum creatinine (Acute Kidney Injury)
Change in serum creatinine (in mL) after rapid sequence intubation and development of Acute Kidney Injury as defined by ≥0.3 mg/dL (≥26.5 micromol/L) within 48 hours
Time frame: 24 hours after Rapid Sequence Intubation
Acute Kidney Injury
Change in urine output (in mL) after rapid sequence intubation and development of Acute Kidney Injury as defined by Urine volume \<0.5 mL/kg/hour for six hours
Time frame: 24 hours after Rapid Sequence Intubation
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