Opioid overdose suppresses brainstem respiratory circuits, causes apnea, and may result in death. Epidural electrical stimulation (EES) at the cervical spinal cord facilitated motor activity in rodents and humans, and we hypothesized that EES of the cervical spinal cord could antagonize opioid-induced respiratory depression in humans. In this study, we will stimulate the spinal cord during surgery and assess its effects on respiratory function in human patients.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
150
Electrical spinal cord stimulation will be used to modulate respiratory function during general anesthesia.
University of California, Los Angeles
Los Angeles, California, United States
RECRUITINGChange in respiratory frequency
Increase or decrease in respiratory frequency of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Change in respiratory tidal volume
Increase or decrease in respiratory tidal volume of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Change in heart rate
Increase or decrease in heart rate of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
Change in blood pressure
Increase or decrease in blood pressure of 20% during or after stimulation
Time frame: During intraoperative surgery during stimulation and within 2 minutes after stimulation
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