Participants are being asked to take part in this research study because they have had a previous diagnosis (at least 3 months ago) of COVID-19 and are experiencing persistent, recurrent or even new symptoms, i.e. post-acute sequelae of SARS-CoV-2 (PASC). The Investigators are interested in studying the effects of Vitamin K2 (MK-7) and Vitamin D3 supplementation on PASC symptoms and the underlying inflammatory process.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
151
Participants will receive Vitamin K2 (MK-7) daily by mouth.
Participants will receive Vitamin D3 daily by mouth.
University Hospitals Cleveland Medical Center
Cleveland, Ohio, United States
Change in high-sensitivity C-reactive protein (hs-CRP) as measured by blood test
Time frame: Baseline, week 12, week 24
Change in interleukin 6 (IL-6) as measured by blood test
Time frame: Baseline, week 12, week 24
Change in intestinal fatty acid binding protein (Ifab) as measured by blood test
Time frame: Baseline, week 12, week 24
Change in soluble Tumor Necrosis Factor Receptor II ( sTNF-RII) as measured by blood test
Time frame: Baseline, week 12, week 24
Change in Vitamin K2 (MK-7) levels as measured by blood test
Time frame: Baseline, week 12, week 24
Change in Vitamin D3 levels as measured by blood test
Time frame: Baseline, week 12, week 24
Percent of subjects with >Grade 2 adverse events as measured by patient report
Time frame: Up to 24 weeks
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