Investigators are going to conduct a multi-centered randomized clinical trial that myopic children are randomly allocated into three groups: 0.01% atropine, 0.04% atropine and orthokeratology in order to evaluate the efficacy and side effects of different intervention methods and establish a risk factor model to predict the efficacy of myopia intervention, and to provide precise intervention plans and clinical decisions for the control of myopia.
Investigators are going to conduct a multi-centered randomized clinical trial that myopic children are randomly allocated into three groups: 0.01% atropine, 0.04% atropine and orthokeratology in order to evaluate the efficacy and side effects of different intervention methods and establish a risk factor model to predict the efficacy of myopia intervention, and to provide precise intervention plans and clinical decisions for the control of myopia.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
186
use one drop into subconjunctiva
wear orthokeratology at night while sleeping
use one drop into subconjunctiva
Jianfeng Zhu
Shanghai, Shanghai Municipality, China
RECRUITINGspherical equivalent progression in over two years
equals sphere +1/2 cylinder
Time frame: 2 years
axial length change over two years
measured by IOL-Master
Time frame: 2 years
lens power change over two years
calculated by Bennett-Rabetts formula
Time frame: 2 years
choroidal thickness change over two years
measured by SS-OCT
Time frame: 2 years
choroidal blood flow density change over two years
measured by OCTA
Time frame: 2 years
anterior chamber depth change over two years
measured by IOL-Master
Time frame: 2 years
intraocular pressure change over two years
measured by a non-contact tonometer
Time frame: 2 years
corneal topography change over two years
measured by Pentacam
Time frame: 2 years
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