Evaluation of serum gastrin levels and their effect on marginal ulcer formation.
Prospective, randomized, interventional trial. Participants will be randomized to one of two surgical techniques, either with transection of the vagal nerves, or without. Outcomes including compare marginal ulcer rates will be compared using serum gastrin levels before and after surgery and gastric pH during surgery.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
50
Vagal nerve interruption above the level of the stomach is a known treatment for complicated peptic ulcer disease. It is not commonly performed during routine gastric bypass. The vagi are, however, interrupted part-way down the stomach to create the gastric pouch. This is the pars flaccida technique.
Dissection between the neurovascular bundle and the stomach, spareing the vagus nerves. This is the perigastric technique.
Sanford Health
Fargo, North Dakota, United States
Incidence of Marginal Ulcer
Number of participants with a change in serum gastrin levels compared pre- and post-surgery.
Time frame: From surgical intervention to five years after surgery
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