Global collaboRAtion on CIC-DUX4, BCOR-CCN3, High-grade Undifferentiated Round Cell Sarcoma (URCS) Project

Istituto Ortopedico Rizzoli260 enrolled

Overview

Experimental study with biological material : case series review of clinical and histological data

This is a multicenter retrospective and prospective study that will analyze all cases with a diagnosis of Undifferentiated round cell sarcomas from 01 January 1983 and all new cases referring to each participant site.

Study Type

OBSERVATIONAL

Enrollment

260

Conditions

Undifferentiated Round Cell Sarcoma

Interventions

data collection and analysis on Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissueOTHER

Formalin-fixed paraffin embedded tissue and/or frozen tumoral tissue of cases negative for all Ewing's sarcoma molecular fusions, will be analyzed for the presence of CIC-DUX4 / BCOR-CCNB3 translocations fusion at each Institution. Treatment, outcome, and prognostic factors will be related with the molecular re-classification.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with undifferentiated round cell sarcomas treated from 01 January 1983 and all new patients will be included. * Clinical and outcome information available. * Histological slides/formalin-fixed paraffin-embedded tissue tumor blocks from archive available to perform the histology analysis/frozen tissue representative of the tumor available. Exclusion Criteria: * Diagnosis different from undifferentiated round cell sarcomas * Patient with no clinical or outcome information available

Locations (1)

IRCCs Istituto Ortopedico Rizzoli

Bologna, BO, Italy

RECRUITING

Outcomes

Primary Outcomes

event free survival

Correlate clinical and pathological variables with event-free survival and overall-survival in undifferentiated round cell sarcomas.

Time frame: baseline

Central Contacts

Emanuela Palmerini, MD

CONTACT

051.63.66 emanuela.palmerini@ior.it

Marco Gambarotti, MD

CONTACT

051.63.66 marco.gambarotti@ior.it

Data from ClinicalTrials.gov

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