Dual Perfusion Imaging for Characterizing Vascular Architecture of Brain Lesions

University Health Network, Toronto100 enrolled

Overview

The objectives of the study are (1) to evaluate the feasibility of using a combined spin- and gradient- echo (SAGE) sequence in dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) and (2) to determine quantitative estimates of vessel density and size to differentiate between areas of radiation necrosis and tumor recurrence.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

100

Conditions

Brain Tumor Brain Metastases

Interventions

Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI)DIAGNOSTIC_TEST

A dye, known as a contrast agent, will be injected through a needle that is inserted into a vein in the arm or hand. Subsequent magnetic resonance imaging will follow.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Diagnosed with a brain metastasis or primary brain tumour and who will undergo MRI with contrast. Exclusion Criteria: * Subject or subject's legally authorized representative is unable or unwilling to consent to the study. * Subject with documented contrast medium injection contraindication due to severe kidney disease or allergy.

Locations (1)

University Health Network

Toronto, Ontario, Canada

RECRUITING

Outcomes

Primary Outcomes

Measurement of perfusion parameter: cerebral blood volume (CBV)

Measurements of cerebral blood volume (CBV) will be calculated.

Time frame: Baseline to end of study (up to 2 years)

Measurement of perfusion parameter: vessel size index (VSI)

Measurements of vessel size index (VSI) will be calculated.

Time frame: Baseline to end of study (up to 2 years)

Central Contacts

Angelica Manalac

CONTACT

4166035800 dual.perfusion@gmail.com

Data from ClinicalTrials.gov

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