It is unknown what proportion of children have been exposed to SARS-CoV-2 and how many have antibodies among children seeking medical care for non-Covid-19 related conditions. The aim of this study is to identify children with IgG antibodies to SARS-CoV-2 who have not been previously diagnosed and are presumed/confirmed Covid-19 negative, then determine the level of immunity in this population which could inform further decisions about covid-19 vaccine strategies for children
Enrolled participants will have a survey about demographic information, history of previous suspected/confirmed Covid-19 infection or exposed to SARS-CoV-2, Covid-19 vaccination status. For participants aged less than 12 months, participants' mothers' status of Covid-19 vaccination and/or previous infection will be recorded. Participants will then complete serologic testing for SARS-CoV-2 IgG antibodies using residual plasma specimens collected/stored for routine laboratory tests on the date of enrollment. The study will characterize the prevalence of antibody positivity in this population and assess whether there is a correlation between demographic characteristics and antibodies levels.
Study Type
OBSERVATIONAL
Enrollment
4,032
IgG Antibody testing for previous exposure to SARS-CoV-2
Vietnam National Children's Hospital
Hanoi, Vietnam
The percentage of children with IgG SARS-CoV-2 antibodies in Plasma
The percentage of children with IgG SARS-CoV-2 antibodies to the total number of children enrolled in the study
Time frame: 6 month
Immunoglobulins (G) to SARS-CoV-2 in plasma
Mean antibody titres (IgG) to SARS-CoV-2 in plasma using SIEMENS assays
Time frame: 6 month
Measure of association between SARS-CoV-2 IgG seropositivity and characteristics
socio-demographics, previous exposure to SARS-CoV-2
Time frame: 6 month
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.