Effect of Probiotics on Oral Candida Among Denture Wearers

Hams Hamed Abdelrahman50 enrolled

Overview

Forty-eight denture wearers with detectable levels of candida colonization without clinical symptoms will be randomly allocated into two groups: probiotics and placebo. All patients will take a daily dose of chewable tablets (probiotics or placebo according to the assigned group) for 8 weeks. Samples of mouth rinse will be collected from patients at baseline, 4 weeks from the beginning of the intervention, 8 weeks (the end of intervention), and after another 4 weeks for post-intervention follow up. Samples will be tested for both candida count and candida species identification

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Oral Candida Albicans Infection

Interventions

Probiotic groupOTHER

Participants will use the probiotic product once daily (1 tablet/day) for 8 weeks

Placebo groupOTHER

Patients will chew placebo products (blueberry tablets) once daily (1 tablet/day) for 8 weeks.

Eligibility

Sex: ALLMin age: 40 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Detectable levels of Candida in palatal mucosa without clinical symptoms of active candidiasis. * Completely edentulous arches with newly formed denture . * Patients with controlled hypertension, and diabetes will be included in this study as they are considered very common problems in the targeted population. Exclusion Criteria: * Inability to understand/ follow the experimental procedures, * Administration of topic or systemic antifungal or antibacterial agents in the previous 60 days. * Consumption of probiotics. * GITdisorders. * Heartdisease. * Diseases that significantly influence immunity such as; kidney problems, head and neck cancer, or radiotherapy, AIDS, or immunosuppressive therapy. * Clinical manifestations of oral candidiasis.

Locations (1)

Alexandria Faculty of Dentistry

Alexandria, Egypt

Outcomes

Primary Outcomes

Change in candida count

Quantitative culture will be performed from mouth-rinse samples by inoculation onto the surface of Sabouraud dextrose agar plates with chloramphenicol, and subsequent aerobic incubation for 24 to 48 hours at 37°C.

Time frame: Baseline, 4 weeks, 8 weeks, 12 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.